Jian Zhang Selected Research

Gemcitabine

7/2023	Saikosaponin D reverses epinephrine- and norepinephrine-induced gemcitabine resistance in intrahepatic cholangiocarcinoma by downregulating ADRB2/glycolysis signaling.
12/2022	A randomized phase 3 trial of Gemcitabine or Nab-paclitaxel combined with cisPlatin as first-line treatment in patients with metastatic triple-negative breast cancer.
1/2022	Comparison of two regimens of weekly paclitaxel plus gemcitabine in patients with metastatic breast cancer: propensity score-matched analysis of real-world data.
1/2022	Phase 1b clinical trial of pucotenlimab (HX008), a novel anti-PD-1 monoclonal antibody, combined with gemcitabine and cisplatin in the first-line treatment of metastatic triple-negative breast cancer.
1/2021	ABCA8-mediated efflux of taurocholic acid contributes to gemcitabine insensitivity in human pancreatic cancer via the S1PR2-ERK pathway.
1/2021	Exosomal annexin A6 induces gemcitabine resistance by inhibiting ubiquitination and degradation of EGFR in triple-negative breast cancer.
1/2019	Gemcitabine enhances OSI-027 cytotoxicity by upregulation of miR-663a in pancreatic ductal adenocarcinoma cells.
1/2019	Gemcitabine plus cisplatin versus fluorouracil plus cisplatin as a first-line concurrent chemotherapy regimen in nasopharyngeal carcinoma: a prospective, multi-institution, randomized controlled phase II study.
1/2019	Triptolide enhances the sensitivity of pancreatic cancer PANC-1 cells to gemcitabine by inhibiting TLR4/NF-κB signaling.
1/2019	aPKCι promotes gallbladder cancer tumorigenesis and gemcitabine resistance by competing with Nrf2 for binding to Keap1.

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Jian Zhang Research Topics

Disease

1134	Neoplasms (Cancer) 05/2024 - 07/2002
197	Breast Neoplasms (Breast Cancer) 05/2024 - 02/2002
196	Inflammation (Inflammations) 05/2024 - 11/2004
161	Neoplasm Metastasis (Metastasis) 04/2024 - 04/2002
158	Infections 05/2024 - 11/2002
118	Hepatocellular Carcinoma (Hepatoma) 04/2024 - 12/2003
104	Carcinogenesis 01/2024 - 07/2003
99	Lung Neoplasms (Lung Cancer) 02/2024 - 12/2004
93	Heart Failure 06/2024 - 06/2002
84	Fibrosis (Cirrhosis) 05/2024 - 08/2003
79	Necrosis 03/2024 - 12/2004
75	Hypoxia (Hypoxemia) 04/2024 - 10/2007
74	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/2024 - 12/2002
69	Myocardial Infarction 12/2023 - 05/2005
64	Colorectal Neoplasms (Colorectal Cancer) 05/2024 - 04/2002
62	Stomach Neoplasms (Stomach Cancer) 04/2024 - 09/2006
60	Prostatic Neoplasms (Prostate Cancer) 03/2023 - 10/2003
57	Carcinoma (Carcinomatosis) 12/2023 - 10/2003
52	Pain (Aches) 04/2024 - 04/2005
52	Body Weight (Weight, Body) 02/2024 - 06/2003
50	Wounds and Injuries (Trauma) 04/2024 - 08/2003
48	Alzheimer Disease (Alzheimer's Disease) 03/2024 - 09/2003
48	Glioma (Gliomas) 10/2023 - 04/2008
45	Stroke (Strokes) 03/2024 - 12/2004
43	Cardiovascular Diseases (Cardiovascular Disease) 01/2024 - 07/2006
41	Adenocarcinoma of Lung 03/2024 - 04/2008
41	Nasopharyngeal Carcinoma 02/2024 - 04/2011
40	Reperfusion Injury 01/2024 - 05/2007
39	Ischemia 03/2024 - 01/2006
39	Infarction (Infarctions) 01/2024 - 05/2005
37	Hemorrhage 04/2024 - 11/2003
36	Obesity 04/2024 - 02/2004
34	COVID-19 05/2024 - 01/2020
34	Osteosarcoma (Osteogenic Sarcoma) 03/2024 - 10/2003
33	Glioblastoma (Glioblastoma Multiforme) 02/2024 - 08/2008
33	Triple Negative Breast Neoplasms 01/2024 - 02/2014
32	Thrombosis (Thrombus) 01/2024 - 04/2005
31	Colonic Neoplasms (Colon Cancer) 04/2024 - 02/2005
31	Ischemic Stroke 03/2024 - 07/2010
31	Hypertension (High Blood Pressure) 03/2024 - 03/2007
31	Type 2 Diabetes Mellitus (MODY) 12/2023 - 01/2007
30	Disease Progression 04/2024 - 11/2008
30	Asthma (Bronchial Asthma) 06/2023 - 04/2005
29	Adenocarcinoma 03/2024 - 02/2005
29	Cognitive Dysfunction 01/2024 - 02/2006
28	Pancreatic Neoplasms (Pancreatic Cancer) 11/2023 - 09/2008
27	Leukemia 12/2023 - 06/2005
26	Myocardial Ischemia (Ischemic Heart Diseases) 12/2023 - 05/2007
25	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 05/2024 - 08/2015
25	Neuroinflammatory Diseases 03/2024 - 09/2007

Drug/Important Bio-Agent (IBA)

386	Proteins (Proteins, Gene)FDA Link 05/2024 - 07/2002
220	Biomarkers (Surrogate Marker)IBA 05/2024 - 07/2005
141	MicroRNAs (MicroRNA)IBA 04/2024 - 06/2010
133	Messenger RNA (mRNA)IBA 05/2024 - 08/2002
118	CytokinesIBA 05/2024 - 01/2003
81	RNA (Ribonucleic Acid)IBA 05/2024 - 10/2008
80	EnzymesIBA 05/2024 - 07/2002
74	Long Noncoding RNAIBA 01/2024 - 08/2014
72	DNA (Deoxyribonucleic Acid)IBA 01/2023 - 08/2002
63	Immune Checkpoint InhibitorsIBA 05/2024 - 01/2018
61	AntigensIBA 11/2023 - 02/2002
60	Peptides (Polypeptides)IBA 05/2024 - 09/2003
60	Glucose (Dextrose)FDA LinkGeneric 01/2024 - 03/2004
56	Therapeutic UsesIBA 12/2023 - 03/2004
54	LigandsIBA 12/2023 - 01/2003
52	Small Interfering RNA (siRNA)IBA 08/2023 - 06/2006
50	Transcription Factors (Transcription Factor)IBA 05/2024 - 06/2007
48	Interleukin-6 (Interleukin 6)IBA 04/2023 - 02/2006
45	Cisplatin (Platino)FDA LinkGeneric 05/2024 - 12/2002
43	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2023 - 11/2003
42	Hormones (Hormone)IBA 02/2024 - 05/2003
41	LipidsIBA 11/2023 - 02/2004
37	Doxorubicin (Adriamycin)FDA LinkGeneric 05/2024 - 08/2011
36	LipopolysaccharidesIBA 03/2024 - 06/2003
36	CateninsIBA 12/2023 - 02/2012
35	CollagenIBA 04/2024 - 01/2003
35	Phosphotransferases (Kinase)IBA 01/2024 - 07/2010
34	Circular RNAIBA 02/2024 - 01/2019
33	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2024 - 12/2009
32	AntioxidantsIBA 05/2024 - 11/2004
32	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 02/2004
31	Oxygen (Dioxygen)IBA 03/2024 - 05/2006
30	VaccinesIBA 01/2024 - 03/2007
29	pro-brain natriuretic peptide (1-76)IBA 01/2024 - 05/2006
29	Interleukin-10 (Interleukin 10)IBA 05/2023 - 01/2003
28	Indicators and Reagents (Reagents)IBA 04/2024 - 01/2010
28	ErbB Receptors (EGF Receptor)IBA 03/2024 - 05/2008
27	Insulin (Novolin)FDA Link 02/2024 - 09/2003
26	Antiviral Agents (Antivirals)IBA 08/2023 - 07/2011
25	ChemokinesIBA 12/2023 - 06/2007
25	CholesterolIBA 07/2023 - 09/2003
25	Anti-Bacterial Agents (Antibiotics)IBA 10/2022 - 02/2004

Therapy/Procedure

485	Therapeutics 05/2024 - 10/2003
193	Drug Therapy (Chemotherapy) 05/2024 - 04/2002
140	Immunotherapy 04/2024 - 04/2004
80	Radiotherapy 05/2024 - 12/2008
48	Transplantation 02/2024 - 10/2003
27	Stents 08/2023 - 04/2005
27	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/2022 - 06/2007
25	Liver Transplantation 04/2024 - 08/2007